49ers VS Seahawks Picks, Predictions, and Odds

San Francisco 49ers VS Seattle Seahawks Best Bets - November 23rd

NFL Thanksgiving Day Picks - 49ers VS Seahawks

Capping off an exciting day full of NFL action, we’ve got a tremendous matchup set for the third-leg of this holiday tripleheader as the San Francisco 49ers take on the Seattle Seahawks in an NFC West showdown. With both teams looking to maintain their postseason position, tonight’s tilt is sure to be jam-packed with intensity.

The only way that the stakes of tonight’s matchup could get any higher is if you raised them yourself by getting some skin in on the game with our 49ers VS Seahawks picks, predictions, and odds.

At Canadian Sports Betting, we provide you with expert insight and analysis on the NFL so you can find all the top moneymaking picks and predictions available on tonight’s tilt. Along with our best bets on the 49ers VS Seahawks, we also supply you with helpful betting resources that can take your winning ability to the next level.

If you’re looking to throw down a wager on tonight’s 49ers VS Seahawks matchup but aren’t sure where to take your action, be sure to check out our in-depth reviews on the best sports betting sites in Canada.

After carefully vetting each of the top Ontario sportsbooks on the market, we’ve compiled the best bookmakers in Canada into one spot so you can find a trusted and reliable oddsmaker with ease.

Sign up today with the top NFL sportsbook in Canada that’s right for you using the links provided on-site, and net your next big win using our 49ers VS Seahawks picks, predictions, and odds.

49ers VS Seahawks Odds

TeamMoneyline OddsPoint Spread OddsOver/Under Odds
San Francisco 49ers-360(-7.5) -112(O 44) -105
Seattle Seahawks+285(+7.5) -108(U 44) -115

Odds Courtesy of DraftKings Ontario Sportsbook as of November 23rd, 2023

49ers VS Seahawks Injury Report

49ers VS Seahawks Best Bets

Moneyline/Point Spread Pick: San Francisco 49ers (ML/-7.5)

Primed to continue their run of dominance over the NFC West, look for the 49ers to score the dominant victory over the Seahawks in tonight’s Thanksgiving clash.

After falling to the Los Angeles Rams in Week 11 by a single-point, the Seahawks have continued to show signs of weakness. With starting quarterback Geno Smith entering this short-week duel at less than 100-percent, while starting running back Kenneth Walker III is going to be missing the game entirely, look for the ferocious 49ers to have a field day against their division rivals.

Having won back-to-back games, the 49ers have continued to ride the wave of momentum as they trudge their way toward another Super Bowl run. Look for them to quickly impose their will over the Seahawks with their sensational run-game before attacking over the top with deep shots to their well-rounded receiving core.

Bank on the 49ers to take the win in tonight’s final matchup, covering the 7.5-point spread as favourites, earning you a hefty payout on this evening’s action.

Over/Under Pick: Under 44 Points

Set to be a one-sided affair, watch as the 49ers take pleasure in controlling the pace of the contest, draining the clock with their methodical offensive game plan as Under 44 points are scored in tonight’s duel.

While the Seahawks are always eager to take deep shots toward the end zone when in possession of the football, look for scoring chances to come at a premium as the take on a 49ers squad that excels at taking command of the game early.

With their high-powered defence hungry to steamroll the shorthanded Seahawks, look for the 49ers to have no trouble mitigating the offensive production of Seattle. Once in control of the football look for the 49ers to easily move the ball downfield on the ground, milking the clock, and securing safe scoring plays as a result.

Hammer the Under on the 49ers VS Seahawks as both sides enter tonight’s contest having finished 60% of their games played with the Under hitting. Fade the total amount of points scored in this marquee matchup and watch as your bankroll skyrockets while the scoreboard remains stagnant.

49ers VS Seahawks Player Prop Bets

Brandon Aiyuk Anytime Touchdown Scorer (+145)

Looking to stay hot in this featured matchup, back 49ers wide receiver Brandon Aiyuk to finish tonight’s contest as an anytime touchdowns scorer against the Seahawks.

Having hauled in a touchdown pass in back-to-back games played, look for the touchdown streak of Aiyuk to extend on Thanksgiving as he finds an opening against the Seahawks this evening. With the Seahawks set to struggle containing the physical wideout in the red zone, look for Aiyuk to rise up and snag an easy grab for six-points tonight.

Back Aiyuk as an anytime touchdown scorer against the Seahawks and hit paydirt this evening alongside the 49ers receiver.

Tyler Lockett Over 50.5 Receiving Yards (-115)

Hoping to provide his team with a spark offensively this evening, back Seahawks wide receiver Tyler Lockett to pile up Over 50.5 receiving yards against the 49ers.

With the Seahawks set to play from behind for the majority of tonight’s clash, look for them to take deep shots downfield repeatedly as they look to stay within striking distance of the lead. Serving as one of the top deep route threats for the Seahawks, bank on Lockett to haul in ample yardage against a 49ers seconday that gives up 221.4 yards per game.

Bet the Over on Lockett’s receiving yard total and watch as your account balance rises alongside his receiving yard tally.

49ers VS Seahawks Same Game Parlay

Easily one of the best ways to bet on the NFL, same game parlays allow for bettors to combine game lines and prop bets into single wagers. With each bet selection added to your parlay, your potential payout continues to increase.

In order to be paid out as a winner each pick entered must hit, if any are unsuccessful your bet results in a loss.

Craft your next bet carefully or take advantage of our pre-built 49ers VS Seahawks same game parlay found below.

  • Christian McCaffrey Over 75.5 Rushing Yards
  • D.K. Metcalf Over 58.5 Receiving Yards
  • Race to 20 Points - 49ers

Total Odds: (+330)

49ers VS Seahawks Public Betting Trends

After gathering information regarding where the majority of bets are being placed on tonight’s game, you can see exactly where the popular money resides with the latest 49ers VS Seahawks public betting trends.

By seeing where most bettors are leaning ahead of kickoff in tonight’s tilt, you can use this information to influence your own bet slip on the 49ers VS Seahawks.


San Francisco 49ers - 88%

Seattle Seahawks - 12%

Point Spread

San Francisco 49ers (-7.5) - 75%

Seattle Seahawks (+7.5) - 25%


Over 44 Points - 62%

Under 44 Points - 38%

Best Odds & Lines on the 49ers VS Seahawks

Score yourself the biggest payout possible on the 49ers VS Seahawks by placing your bets with the top online sportsbooks in Canada offering the best odds & lines.

Find the betting market you wish to wager on below, follow our direct links to the applicable oddsmaker offering the best value, sign up, and maximize your winning potential on all of your 49ers VS Seahawks bets this evening.


San Francisco 49ers - FanDuel (-330)

Seattle Seahawks - BetMGM (+290)

Point Spread

San Francisco 49ers (-7.5) - BetMGM (-105)

Seattle Seahawks (+7.5) - Bet365 (+100)


Over 44 Points - DraftKings (-105)

Under 44 Points - FanDuel (-105)

Looking for the latest NFL Betting News? Get the best NFL picks & predictions as well as helpful betting guides and tools.

Get exclusive moneymaking picks when you follow us @cdnbetting on Twitter and @canadiansportsbetting on TikTok.

Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.