NFL Playoffs Best Bets: Chiefs VS Bills Picks, Predictions, and Odds

Kansas City Chiefs VS Buffalo Bills Best Bets - January 21st

NFL Divisional Round Picks - Chiefs VS Bills

Facing off for the third time in the postseason in four years the Kansas City Chiefs will look to defend their place atop the NFL as they take on a hungry Buffalo Bills squad. With no love lost between these two squads, tonight’s playoff showdown is sure to be chock-full of fireworks as we get the trilogy matchup between Patrick Mahomes VS Josh Allen.

In what is sure to be the most highly-anticipated clash of the 2023 Divisional Round, why not cap off your NFL betting with a win using our Chiefs VS Bills picks, predictions, and odds?

At Canadian Sports Betting, we provide expert insight and analysis on the NFL Playoffs so you can load your bet slip full of winning wagers this postseason. Below we’ve featured our Chiefs VS Bills best bets so you can hit paydirt while watching the action unfold.

If you’re interested in getting some skin in on the game this evening but aren’t sure where to take your action, be sure to check out our in-depth betting site reviews of the best Canadian sportsbooks available.

After carefully vetting each of the top Ontario sportsbooks on the market, we’ve compiled the best bookmakers in Canada into one spot so you can easily find the oddsmaker that’s right for you.

Sign up today using the links provided on-site to the top NFL sportsbook in Canada that’s right for you and score your first big win using our Chiefs VS Bills picks, predictions, and odds.

Chiefs VS Bills Odds

TeamMoneyline OddsPoint Spread OddsOver/Under Odds
Kansas City Chiefs+124(+2.5) +100(O 45.5) -110
Buffalo Bills-148(-2.5) -120(U 45.5) -110

Odds Courtesy of DraftKings Ontario Sportsbook as of January 21st, 2024

Chiefs VS Bills Injury Report

Chiefs VS Bills Best Bets

Moneyline/Point Spread Pick: Buffalo Bills (ML/-2.5)

After picking up the hard-fought victory against the Chiefs earlier this season, bank on the Bills to advance to the AFC Championship game as they cover the spread as favourites in tonight’s marquee matchup.

In what is sure to be an evenly matched duel, look for the high-end talent of the Bills to provide them with a winning edge over the Chiefs.

With Josh Allen playing at an elite level, coupled with their standout defensive unit, look for the Chiefs to struggle generating big plays against the Bills, falling behind on the scoreboard early on into tonight’s tilt.

Expect to see the Bills apply pressure right off the get go in tonight’s win-or-go-home matchup, sending heavy blitz packages defensively, while taking deep shots downfield in order to generate offence. While the Chiefs defence has been strong throughout the 2023 season, look for them to have trouble containing the high-octane output of the Bills.

Back the Bills to keep the Patrick Mahomes and company in check throughout tonight’s game, forcing them into hard-fought methodical drives, limiting their total output on each and every down played.

Back the Bills to cover the single-score spread in tonight’s Divisional Round showdown and watch as the Bills finally get the upper hand on the Chiefs as they punch their ticket to the AFC Championship game.

Over/Under Pick: Over 45.5 Points

In a battle between two of the top quarterback talents the league has seen over the last decade, look for tonight’s matchup to turn into a shootout quickly as Over 45.5 points are scored.

When Mahomes and Allen have squared off in the past, high-scoring contests have often been the result. While their regular season meeting this season resulted in just 37 total points, in the postseason both sides have exploded in offensive production.

With final scores of 42-36 and 38-24 in their previous head-to-head duels in the playoffs, both matchups finishing in favour of the Chiefs, look for both sides to throw haymakers immediately as they hunt for the knockout blow in tonight’s clash.

Both sides of this matchup have established themselves as dangerous squads that can score at any given moment, expect to see no shortage of scoring-drives in tonight’s duel as Over 45.5 points are scored in the Chiefs VS Bills.

Chiefs VS Bills Player Prop Bets

Isiah Pacheco Anytime Touchdown Scorer (+115)

Having emerged as one of the top playmakers on the Chiefs offence in 2023, look for running back Isiah Pacheco to continue making his mark in the NFL as he finds the end zone at anytime in tonight’s contest.

Having scored a touchdown in four of his last five games played, it’s clear to see that Pacheco is one of the Chiefs top scoring options on any given down. With sensation downhill running ability, look for Pacheco to enforce his will upon Bills defenders as he crashes his way into the end zone for six-points this evening.

Bank on Pacheco to score a touchdown against the Bills this evening and watch as he nets you a hefty payout thanks to this plus-money player prop bet.

Josh Allen Over 226.5 Passing Yards (-115)

Looking to put his team on his back in order to finally defeat their AFC rivals in the Chiefs, look for Bills quarterback Josh Allen to let the pigskin fly this evening as he passes for Over 226.5 yards.

After averaging a tremendous 253.29 passing yards per game in the 2023 regular season, look for Allen to continue using his cannon of an arm to lead his team to victory in the Divisional Round.

Having passed for 233 yards in his last outing against the Chiefs, look for Allen to have no problems connecting with his receivers throughout tonight’s contest.

Hammer the Over on Allen’s passing yard total as he takes ample shots downfield, connecting with his sure-handed receivers, and securing a statement making performance as he exceeds 226.5 passing yards against the Chiefs.

Chiefs VS Bills Same Game Parlay

Easily one of the best ways to bet on the NFL Playoffs, same game parlays allow bettors to combine game lines and prop bets into a single bet slip. Bettors can receive increased odds for each bet selection added to your same game parlay, resulting in big wins on small wager amounts.

In order to win your Chiefs VS Bills same game parlay, bettors must hit on each pick featured in their bet, if any come up short the entire wager results in a loss.

Craft your next bet carefully or take advantage of the juicy pre-built Chiefs VS Bills same game parlay found below in order to earn your next NFL Playoff payday.

  • Isiah Pacheco Under 61.5 Rushing Yards
  • James Cooke Under 61.5 Rushing Yards
  • Dalton Kincaid Over 38.5 Receiving Yards

Total Odds: (+500)

A helpful betting resource that provides information regarding how other bettors are placing their bets on the Chiefs VS Bills, be sure to check out the latest public betting trends on tonight’s clash below.

By seeing where the popular money resides on today’s game, you can use the latest Chiefs VS Bills public betting trends to influence your NFL Playoffs bet slip this evening.


Kansas City Chiefs - 46%

Buffalo Bills - 54%

Point Spread

Kansas City Chiefs (+2.5) - 69%

Buffalo Bills (-2.5) - 31%


Over 45.5 Points - 79%

Under 45.5 Points - 22%

Best Odds & Lines on the Chiefs VS Bills

Maximize your winning potential on the Chiefs VS Bills by placing your bets with the top online sportsbooks in Canada offering the best odds & lines on the Chiefs VS Bills.

Find the betting market you wish to wager on below, follow our direct link to the applicable oddsmaker offering the best value, sign up, and score the biggest payout possible on your Chiefs VS Bills bets today.


Kansas City Chiefs -Bet365 (+124)

Buffalo Bills - BetMGM (-145)

Point Spread

Kansas City Chiefs (+2.5) - Sports Interaction (+100)

Buffalo Bills (-2.5) - NorthStar Bets (+102)


Over 45.5 Points - DraftKings (-110)

Under 45.5 Points - DraftKings (-110)

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Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.