Giants VS 49ers Picks, Predictions, and Odds

New York Giants VS San Francisco 49ers Best Bets - September 21st

Thursday Night Football Picks - Giants VS 49ers

The first two weeks of the 2023 NFL season have come to an end and there’s already been an abundance of highlight reel moments and jaw-dropping action. Showing no signs of slowing down, look for the NFL to continue bringing the electricity as we kickoff Week 3 with the New York Giants taking on the San Francisco 49ers.

As both teams go toe-to-toe on primetime, why not raise the stakes of this evening’s duel by placing a bet on the Giants VS 49ers?

At Canadian Sports Betting, we provide expert sports gambling advice so you can find the best bets and winning wagers on the market ahead of tonight’s action. Along with our top moneymaking picks and predictions, we also supply you with helpful betting resources that can take your winning potential to new heights.

If you’re looking to get some skin in on the game but aren’t sure where to go, be sure to check out our in-depth reviews on the best sports betting sites in Canada.

After heavily vetting each of the top Ontario sportsbooks on the market, we’ve compiled the best NFL betting sites in the Great White North into one place so you can find a trusted and reliable oddsmaker with ease.

Sign up today with the links provided to the online sportsbook that’s right for you and throw down your first bet with our Giants VS 49ers picks, predictions, and odds.

Giants VS 49ers Odds

TeamMoneyline OddsPoint Spread OddsOver/Under Odds
New York Giants+410(+10) -108(O 44.5) -110
San Francisco 49ers-520(-10) -112(U 44.5) -110

Odds Courtesy of DraftKings Ontario Sportsbook as of September 21st, 2023

Giants VS 49ers Injury Report

Giants VS 49ers Best Bets

Moneyline/Point Spread Pick: San Francisco 49ers (ML/-10)

After taking care of business against a pesky divisional rival in the Los Angeles Rams in Week 2, look for the 49ers to continue their undefeated streak to kickoff the 2023 season as they dominate the Giants at home on Thursday Night Football.

With the Giants seemingly reverting to their old ways, it will take a lot more than a comeback victory against a lowly Cardinals team to prove that they can be taken seriously. With their offence set to be without the services of star running back Saquon Barkley, expect the 49ers to turn this matchup into a blow out in a hurry.

Sporting a fierce defence as well as a high-powered offence, the 49ers have continued to establish themselves as potential Super Bowl contenders early this season. With a sensational run-game as well as terrific playmakers at receiver, the Giants without Barkley will have no chance in keeping up with the 49ers this evening.

Hammer the 49ers to cover the 10-point spread against the Giants, finishing the game with a lopsided final score en route to their third-straight win of the 2023 season.

Over/Under Pick: Under 44.5 Points

With the Giants set to be devoid of offensive production on Thursday Night Football, look for the 49ers to command the lead early and sit on it as Under 44.5 total points are scored this evening.

Possessing a plethora of dangerous scoring threats, the 49ers have multiple reliable weapons to utilize in tonight’s tilt. With the Giants defence unable to stop a nosebleed, look for the 49ers to quickly move into scoring range as they march into the opposing end zone.

Once they’ve built up a multi-score lead, look for them to play it safe, running the rock, and draining the clock in order to secure the victory.

With the Giants unlikely to put up much in the scoring department, coupled with the ball dominant playstyle of the 49ers, expect a low-scoring game tonight as Under 44.5 total points are scored.

Giants VS 49ers Player Prop Bets

Darren Waller Under 45.5 Receiving Yards (-115)

While he acted as one of the top receiving options for Giants in their come from behind win against the Cardinals last week, look for a diminished output for tight end Darren Waller in Week 3.

Facing one of the best defensive units in the NFL, look for the incredibly skilled linebackers of the 49ers to lockdown the big-bodied pass-catcher as they hold him to Under 45.5 receiving yards. With the 49ers having only allowed 34 total yards against to tight ends so far this season, don’t expect to see a bountiful evening for Waller on primetime.

Fade the output of the former-Pro Bowl tight end as he struggles to find openings in the 49ers defence, finishing with Under 45.5 receiving yards in tonight’s clash.

Christian McCaffrey Over 79.5 Rushing Yards (-130)

Continuing to put up video game stat lines on a week-to-week basis, look for 49ers running back Christian McCaffrey to run all over the defence of the Giants in tonight’s Thursday Night Football throw down.

Having amassed more than 100 yards rushing in back-to-back weeks to kickoff his 2023 campaign, look for McCaffrey to have no trouble trampling over the Giants defenders this evening. With the G-Men having allowed Over 100 rushing yards to opposing running backs in both of their games played this season, you can expect a massive output from CMC in tonight’s showdown.

Bank on McCaffrey to put on a show under the bright lights, easily hitting the Over on his total rushing yards as he blows by the Giants defence as he blazes downfield regularly in tonight’s contest.

Giants VS 49ers Same Game Parlay

One of the best ways to bet on the NFL, same game parlays allow bettors to combine game lines and prop bets into a single bet slip with increased odds for each pick added. In order to be paid out as a winner, each bet selection added must hit, if any come up short, your wager results in a loss.

Craft your Giants VS 49ers Same Game parlay wisely or make use of our juicy pre-built bet found below to help you land your next win.

  • Daniel Jones Under 37.5 Rushing Yards
  • Brandon Aiyuk Anytime Touchdown Scorer
  • San Francisco 49ers to Score First

Total Odds: (+470)

A helpful betting resource that you can utilize to help elevate your winning potential, the latest Giants VS 49ers public betting trends may supply you with a winning edge on your upcoming bets placed. By seeing where the majority of wagers are being placed by other bettors, you can use this to help influence your Thursday Night Football bet slip.

Check out the latest Giants VS 49ers public betting trends found below and utilize this betting tool to generate your next winning wager on tonight’s action.


New York Giants - 4%

San Francisco 49ers - 96%

Point Spread

New York Giants (+10) - 33%

San Francisco 49ers (-10) - 67%


Over 44.5 Points - 89%

Under 44.5 Points - 11%

Best Odds & Lines on the Giants VS 49ers

Want to score the best bang for your buck on Thursday Night Football? Then be sure to place your next bet with the top online sportsbook offering the best odds & lines on the Giants VS 49ers.

After compiling all of the best odds available for the major betting markets on the Giants VS 49ers, you can easily find the oddsmaker that secures you the biggest payout possible on tonight’s clash.

Simply find the bookmaker that offers the best value on the betting market you’re interested in wagering on, follow our direct links to the applicable sportsbook, sign up, and throw down your next bet with maximized winning potential.


New York Giants - DraftKings (+425)

San Francisco 49ers - Bet365 (-550)

Point Spread

New York Giants (+10) - FanDuel (-105)

San Francisco 49ers (-10) - BetMGM (-110)


Over 44.5 Points - DraftKings (-108)

Under 44.5 Points - FanDuel (-105)

Looking for the latest NFL Betting News? Get the best NFL picks & predictions as well as helpful betting guides and tools.

Get exclusive moneymaking picks when you follow us @cdnbetting on Twitter and @canadiansportsbetting on TikTok.

Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.