NFL Playoffs Best Bets: Lions VS 49ers Picks, Predictions, and Odds

Detroit Lions VS San Francisco 49ers Best Bets - January 28th

NFL Conference Championship Picks - Lions VS 49ers

Set to cap off Championship Sunday with a thrilling bout between two of the most explosive teams in the NFL, the Detroit Lions will look to finally make their first Super Bowl appearance as they take on the San Francisco 49ers.

With the NFC Championship and a trip to Super Bowl LVIII on the line in tonight’s game, you can raise the stakes even higher by placing a bet on the Lions VS 49ers with our expert picks and predictions.

At Canadian Sports Betting, we provide expert insight and analysis on the NFL so you can score big wins while enjoying the nonstop action of the Playoffs. Along with our Lions VS 49ers best bets found below, we also supply you with helpful betting resources that can take your winning potential to the next level.

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Sign-up today using the links provided to any of the top NFL sportsbooks in Canada found on-site and score your first big win using our Lions VS 49ers picks, predictions, and odds.

Chiefs VS Ravens Odds

TeamMoneyline OddsPoint Spread OddsOver/Under Odds
Detroit Lions+270(+7.5) -122(O 51.5) -112
San Francisco 49ers-340(-7.5) +102(U 51.5) -108

Odds Courtesy of DraftKings Ontario Sportsbook as of January 28th, 2024

Lions VS 49ers Injury Report

Lions VS 49ers Best Bets

Moneyline/Point Spread Pick: San Francisco 49ers (ML/-7.5)

Primed to capture a dominant win on home turf in order to secure their spot in the Super Bowl, look for the 49ers to record a one-sided beatdown as they crush the hearts of the Lions this evening.

Simply possessing the more experienced and talented team, look for the incredibly depth of the 49ers to lead them to victory as they cover the spread against the Lions this evening. After pulling out a nail-biter victory against the Green Bay Packers last week, the 49ers have proven they can battle through adversity thanks to their top-end talent.

With the Lions defence unable to consistently string together stops, having allowed the 10th-most points against per game in the NFL during the regular season, look for the high-powered 49ers to have no trouble finding their way into the end zone.

Watch as the 49ers control play at the line of scrimmage on both sides of the football, producing methodical drives downfield as they chew away at the game clock, while pulling ahead on the scoreboard.

Bank on the 49ers to cover the spread as favourites this evening, putting an end to the Lions Cinderella season, and capturing their second NFC Championship in five seasons.

Over/Under Pick: Under 51.5 Points

As the 49ers command the tempo of tonight’s ball game by controlling possession of the football and forcing the Lions into a dogfight, look for the score to remain relatively low in this evening’s contest as they combine for Under 51.5 points.

With the Lions set to struggle to produce on the ground as they face a rare mismatch within the trenches, look for them to rely on deep shots downfield in order to generate offence. With this high-risk, high-reward style of play, look for the Lions to be boom-or-bust on each drive.

When you combine the Lions inconsistent scoring offence with the 49ers ability to wear down teams as they chip away on the inside, look for time to quickly drain from the clock, leaving both sides unable to score at their usual pace.

Hammer the Under on the Lions VS 49ers and watch as the score stays low in order to win you the dough with this point total pick.

Lions VS 49ers Player Prop Bets

Jared Goff Over 260.5 Passing Yards (-110)

After throwing for Over 260.5 passing yards in both postseason appearances made this season, look for Lions quarterback Jared Goff to continue letting the pigskin fly as he piles up passing yardage this evening.

With a deadly accurate arm when throwing deep, Goff is able to pick apart opposing defences with precision when in control of the football. Facing a 49ers defence that has proven vulnerable against elite passing-attacks, watch as Goff takes the top off the defence and connects with his recievers for deep shots downfield.

Bet the Over on Goff’s passing yard total this evening as he tallies Over 260.5 yards through the air, netting you an easy payday on this player prop bet.

Christian McCaffrey Over 86.5 Rushing Yards (-115)

Looking to continue his sensational 2023 season in the biggest game of the season, look for 49ers running back Christian McCaffrey to rush for Over 86.5 yards against the Lions.

While the Lions sported a terrific rushing defence throughout the 2023 regular season, look for them to struggle containing the elite ability of McCaffrey. Able to be used as an ellusive back outside the tackles or as a powerful downhill runner between the line, McCaffrey is one of the most unstoppable forces in the modern NFL.

After racking up 98 yards on the ground against the Packers last week, look for him to have no trouble repeating his successes as he plows his way down the field against the Lions this evening.

Bet the Over on McCaffrey’s rushing yard total and watch as your bankroll rises alongside his final rushing yard tally in tonight’s showdown.

Lions VS 49ers Same Game Parlay

One of the best ways to bet on the NFL Playoffs, same game parlays are as exciting as they are profitable. Allowing for bettors to combine game lines and prop bets into a single bet slip, bettors can earn increased payouts for every bet selection included.

In order to win your Lions VS 49ers same game parlay, each pick featured must hit. If any bets included in your parlay happen to come up short, the entire wager results in a loss.

Craft your next bet carefully or take advantage of the juicy pre-built wager found below to help land you your next big-time payday on the Lions VS 49ers.

  • David Montgomery Under 42.5 Rushing Yards
  • Brock Purdy Under 279.5 Passing Yards
  • George Kittle Anytime Touchdown Scorer

Total Odds: (+500)

Allowing for bettors to see where others are leaning ahead of kickoff in tonight’s tilt. the latest Lions VS 49ers public betting trends can provide you with helpful insight in tonight’s contest.

Check out where the popular money resides below and factor this into your upcoming bets placed on the Lions VS 49ers in order to secure your next winning wager on the NFL Playoffs.


Detroit Lions - 30%

San Francisco 49ers - 70%

Point Spread

Detroit Lions (+7.5) - 70%

San Francisco 49ers (-7.5) - 30%


Over 51.5 Points - 25%

Under 51.5 Points - 75%

Best Odds & Lines on the Lions VS 49ers

Want to earn the biggest payday possible on your Lions VS 49ers bets this evening? Then be sure to throw down all your upcoming wagers with the top online sportsbook in Canada offering the best odds & lines on tonight’s contest.

Find the betting market you wish to wager on below, sign up using the links provided to the applicable oddsmaker offering the best odds, and redeem maximized winning potential on all of your Lions VS 49ers bets placed this evening.


Detroit Lions - Bet365 (+280)

San Francisco 49ers - DraftKings (-340)

Point Spread

Detroit Lions (+7.5) - Bet365 (-115)

San Francisco 49ers (-7.5) - BetMGM (+100)


Over 51.5 Points - Sports Interaction (-110)

Under 51.5 Points - DraftKings (-108)

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Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.