NFL Week 1 Sunday Slate Best Bets

Top Picks, Predictions, and Odds on the Afternoon NFL Action in Week 1

NFL Week 1 Best Bets

It’s the best time of the year as the first NFL Sunday rolls around and we are treated to countless hours of football action to enjoy as we cap off the weekend. With several sensational matchups scheduled to go down across the board on Sunday, there’s going to be no shortage of highlight reel moments to enjoy from the afternoon slate of games.

With so much tremendous action about to go down, why not get some skin in on the game by placing a bet on the NFL Week 1 Sunday slate?

At Canadian Sports Betting, we provide expert insight and analysis on the NFL so you can stuff your bet slips full of winning wagers on the Sunday afternoon slate. Below you’ll find the latest NFL Week 1 odds as well as our expert picks and predictions on the upcoming action including point spread picks, underdogs, and player prop bets.

If you’re looking to throw down a wager on the NFL this Sunday but aren’t sure where to get started, we’ve got you covered. After vetting each of the best sports betting sites in Canada, we’ve crafted in-depth reviews on all the best NFL sportsbooks on the market.

See what each of the top Ontario sportsbooks have to offer on the NFL this season with our comprehensive bookmaker reviews, sign up using the links provided, and score your first big win with our NFL Week 1 Sunday slate best bets.

NFL Week 1 Odds

MatchupMoneyline OddsPoint SpreadOver/Under
Texans VS Ravens+350/-450+9.5/-9.5O/U 43.5
Buccaneers VS Vikings+190/-230+5.5/-5.5O/U 46
49ers VS Steelers-130/+110-2.5/+2.5O/U 41.5
Bengals VS Browns-130/+110-2/+2O/U 47.5
Jaguars VS Colts-230/+190-4.5/+4.5O/U 46
Cardinals VS Commanders+260/-325+7/-7O/U 38
Titans VS Saints+130/-155+3/-3O/U 42
Panthers VS Falcons+160/-192+3.5/-3.5O/U 39.5
Eagles VS Patriots-192/+160-4/+4O/U 45
Dolphins VS Chargers+142/-170+3/-3O/U 51
Rams VS Seahawks+190/-230+5/-5O/U 46
Packers VS Bears+105/-125+1.5/-1.5O/U 41.5
Raiders VS Broncos+145/-175+3.5/-3.5O/U 43.5

Odds Courtesy of DraftKings Ontario as of September 10th

NFL Week 1 Expert Picks

San Francisco 49ers (-4)

After coming up short in the NFC Championship game last season, look for the San Francisco 49ers to get their 2023 campaign off on the right foot as they cover the spread as favourites against the Pittsburgh Steelers.

In a clash of ferocious defences, the 49ers offence is far superior when compared to their Week 1 opponents. With the Steelers still in the process of a retooling season, their offence under OC Matt Canada has looked downright ugly. Unable to get the most out of their budding offensive stars, the Steelers ranked 26th in the NFL in points per game.

Bank on the 49ers to easily run up the score in their season opener, besting the Steelers by more than 2.5-points, securing you a safe win on your NFL bet slip.

Philadelphia Eagles (-4)

Poised to go on another run toward the Super Bowl in 2023, look for the Philadelphia Eagles to make quick work of their opponents in their season opener as they demolish the New England Patriots on Sunday afternoon.

Possessing one of the most complete rosters in the NFL, the Eagles are a tough matchup for any team they face. With a terrific team culture and game plan thanks to Head Coach Nick Sirianni, the Eagles are sure to continue building upon their status as a powerhouse in the NFC.

With the Patriots underwhelming for the majority of their 2022 season, look for their slow as molasses offence to struggle keeping up with the dynamic play of the Eagles in Week 1.

Hammer the Eagles to cover the single-score spread, pulling out the lopsided victory, and scoring you an easy payday with this point spread pick.

Bengals VS Browns Over 47.5 Points

In a clash between two heated rivals, look for the bad blood to produce fireworks on the field between the Bengals and Browns this week as they combine for Over 47.5 total points.

With both teams possessing incredible offensive units that can light up the scoreboard in a hurry, this matchup is sure to turn into an shootout in no time. While their last three head-to-head tilts have finished with Under 47.5 points scored, look for this trend to come to screeching halt as these playoff hopefuls turn this into a back-and-forth slugfest.

Bet the Over on the Bengals VS Browns and watch as your bankroll skyrockets as the score quickly rises in this AFC North rivalry clash.

Green Bay Packers (ML)

Looking to make a statement in their first game after the Aaron Rodgers-era, back the underdog Green Bay Packers to storm into Soldier Field and take the win against the Chicago Bears.

While neither team is projected to find much success in 2023, the Packers still possess terrific upside heading into their new season. With the rapid development of building blocks Jordan Love and Christian Watson set to keep the Packers offence alive-and-kicking, look for the Bears defence to struggle containing the explosive output of their young offensive weapons.

On the other side of the football, the Packers still sport one of the top defences in the NFL. Set to face a turnover prone Justin Fields and his porous offensive-line, look for the Packers to eliminate any easy scoring chances, keeping their edge on the scoreboard from start-to-finish.

Bet the Packers on the moneyline to open their 2023 season with a win, handing the Bears their ninth-consecutive loss in head-to-head play, and scoring you a plus-money win with this underdog pick.

DK Metcalf Anytime Touchdown Scorer (+125)

Primed for a big showing against the Los Angeles Rams in his season debut, expect to see a massive performance from Pro Bowl wide receiver as DK Metcalf scores a touchdown in his upcoming game.

Coming off of a six-touchdown season in 2022, Metcalf is poised to dominate in his season opener as he faces arguably the worst-defence in the NFL. After losing the bulk of their defensive starters in the offseason, the Seahawks offence is going to have no problem finding the end zone against their division rivals.

With Metcalf a featured piece in the Seahawks offence, expect to see him earn ample targets in the red zone, using his freakish athleticism and phenomenal size to out muscle defenders, hauling in a touchdown at anytime in Week 1.

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Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.