Sunday Night Football Week 10 Best Bets

All the Best Bets for the Los Angeles Chargers VS San Francisco 49ers

Sunday Night Football Week 10 Picks

It’s time to close out yet another day of thrilling action in the NFL with Sunday Night Football. Tonight’s nightcap will be a battle between California-based teams, as the Los Angeles Chargers travel to San Francisco to take on the 49ers.

At Canadian Sports Betting, we’ve got all the best bets, analysis, and the top odds & lines on tonight’s primetime matchup so you can finish the day on top with a win on Sunday Night Football. In a matchup between two teams with playoff hopes, this tilt is set to be action-packed.

Looking to place a bet on Sunday Night Football Chargers VS 49ers but aren’t sure where to get started? With Canadian Sports Betting, we don’t just provide you with the best bets for every big game, but we have all the best online sportsbooks ranked in one place so you can find your perfect online NFL betting site.

After carefully vetting and reviewing each bookie, use our in-depth sportsbook reviews to find the online sportsbook for you and place your first wager using our best bets on the Chargers VS 49ers on Sunday Night Football.

Signup & Download DraftKings Today

Los Angeles Chargers VS San Francisco 49ers Best Bets

While they may be in the same state, this matchup will be an interconference affair as the Chargers face the 49ers. Both teams enter tonight’s matchup coming off of wins, looking to begin a winning streak as they make a late push toward the playoffs.

The Los Angeles Chargers narrowly escaped with the victory on the road against the Atlanta Falcons in Week 9, winning at the final second off a 37-yard field goal. The Chargers have looked solid this season despite being plagued by injury throughout the year. Entering tonight’s primetime game shorthanded once again, the Chargers will need to bring their A-game to escape with the win.

On the other side if the field, the San Francisco 49ers are well-rested and ready to go on Sunday Night Football. Coming off their bye week, the 49ers roster is looking absolutely stacked as they search to once again reach the Super Bowl this season. After destroying their divisional rival the Los Angeles Rams in their last game, look for the 49ers to make it back-to-back wins against LA teams on Sunday Night Football.

Moneyline/Point Spread Pick: San Francisco 49ers (ML/-7.5)

Possessing arguably the deepest roster on both sides of the football in the NFL, the 49ers are a legitimate threat to capture this years Lombardi Trophy. With dynamic weapons spread across the field on offence, insane athleticism and skill on defence, all held together by one of the best play-callers in the NFL, it’s time to hop on the 49ers hype train.

Looking to make it two consecutive victories, look for the Niners to continue to rely on their brilliant run game to control the pace of the matchup. Able to run the ball well with Christian McCaffrey and Debo Samuel, the 49ers can also pass the ball effectively to either dual-threat player.

With one of the top ranked defences in the NFL behind them as well, the 49ers are as tough as they come for any team that faces them.

Going up against a Chargers squad that will be without their top-two pass-catching weapons in Keenan Allen & Mike Williams once again this week, look for the 49ers defence to terrorize Justin Herbert and company all game long.

Likely relying on Pro Bowler, Austin Ekeler to produce the majority of offensive success for the Chargers, look for the 49ers defence to contain the run and force multiple three-and-out possessions for the Chagers.

Back the 49ers to dominate on Sunday Night Football, from the opening kickoff, to the final kneel down, bet the 49ers to win the game and cover the 7.5-point spread.

Over/Under Pick: Under 45.5 Points

While the 49ers are set to run away with this matchup early on into the game, look for the score to stay conservative, not truly reflecting the dominance on display.

As the 49ers tend to rely on the rushing attack to generate their offence, this strategy is also effective in maintaining the lead. By controlling possession and in turn controlling the clock, the 49ers will milk time off the clock en route to an easy victory.

With long methodical drives set to take place on the side of the 49ers, this will force the Chargers to take chances down field, looking for ways to regain control of the game or at the very least apply pressure against the 49ers. Even when they do get a chance controlling the football, the 49ers defence will prove too strong for the depleted Chargers offence, causing the final score to remain low.

Back the Under in tonight’s Sunday Night Football matchup, as the 49ers control the pace of the game and make this a smashmouth football matchup.

Sunday Night Football Player Prop Bets

Not only are their fantastic bets to be made on the outcome of the Chargers VS 49ers, but there’s several moneymaking wagers to be placed on Sunday Night Football through player prop bets.

Instead of sweating out the final score of a game, focus in on some of the top players involved in tonight’s primetime matchup to create your next winning bet slip. Player prop bets allow you to wager on the performance of your favourite players, betting on them to either reach, or fail to accomplish specific statistical achievements over the course of the game.

Find the top Chargers VS 49ers player prop bets below and add these wagers to your Sunday Night Football bet slip.

Justin Herbert Under 1.5 Passing Touchdowns

One of the brightest young stars in the NFL, Justin Herbert has quickly demonstrated that he is set for a long and successful career at the highest level. While he looks to have a great career ahead of him, tonight will be a game to forget for Herbert.

Without his top two playmakers off the line of scrimmage in Keenan Allen and Mike Williams, Herbert will once again be stuck trying to make plays off of subpar wide receivers. Missing his top two targets downfield will force Herbert and the Chargers to rely on short checkdowns as well as running the ball outright as they will have few opportunities in the passing game against a strong 49ers secondary..

Another factor at play in this matchup is the health of Justin Herbert himself. Still not 100% having played through a nagging rib injury this season, Herbert has had difficulty completing big passes deep downfield.

Look for Herbert to struggle to find his top receivers in tonight’s matchup, resulting in few scoring chances on Sunday Night Football. Bet the Under on Herbert’s total passing touchdowns.

Christian McCaffrey Anytime Touchdown Scorer

One of the most dangerous players in the NFL, Christian McCaffrey has showcased that he is the total package out of the backfield. Able to catch passes as well as he runs the ball, McCaffrey is a threat to score on every single down.

Arguably the best running back in football, McCaffrey has fit perfectly on the 49ers squad and will look to continually provide strong performances each week for his new ball club. Facing a Chargers defence that allows the third-most points against per game, look for McCaffrey to hit paydirt over the course of tonight’s contest.

Cash in on tonight’s Sunday Night Football with this fantastic player prop bet, bet on Christian McCaffrey to score a touchdown at anytime against the Chargers and watch your balance skyrocket.

Chargers VS 49ers Same Game Parlay

One of the best ways to wager on any NFL matchup, same game parlays are a fun, easy, and profitable way to bet on the action of the NFL.

Combine several bet markets into one hand-crafted wager and create your own customized parlay for the Chargers VS 49ers. With no shortage of bets to choose from, find the best bets to fill your bet slip with and clinch your biggest win of the day on Sunday Night Football same game parlays.

  • George Kittle Anytime Touchdown Scorer
  • Austin Ekeler Over 24.5 Receiving Yards
  • Joshua Palmer Over 49.5 Receiving Yards

Total Odds: +400

A great resource when deciding where you want to throw down your bets, check out the NFL public betting trends available below to see where the majority of bettors are placing their money on tonight’s game.

By seeing these numbers, bettors can see where they stand before betting on any game. This can help you decide if you want to stick to your guns and fade the public, or go with the masses and ride with the majority.

Find all the latest NFL public betting trends below.


  • Chargers - 19%
  • 49ers - 81%

Point Spread

  • Chargers - 54%
  • 49ers - 46%


  • Over 45.5 - 56%
  • Under 45.5 - 44%

Chargers VS 49ers Injury Reports

Before you go ahead and place a bet on tonight’s Sunday Night Football game, be sure to check the latest NFL injury reports. Here you can find the latest information as to who will be suiting up, and who is going to be missing in action.

One player could potentially be the difference between a win and a loss, review the latest Chargers VS 49ers injury report and use this information when placing your bets on Sunday Night Football.

Best NFL Sunday Night Football Lines & Odds

If you’re going to bet on tonight’s battle between the Chargers and 49ers, you need to make sure you’re maximizing your winning potential. Below we have all of the best odds & lines on Sunday Night Football so you can bet with the sportsbook that provides the best odds on tonight’s matchup.

Find where you can secure the biggest possible win below and bet with the provided links for each of these top sportsbooks for the Chargers VS 49ers.


Point Spread

  • Chargers - PointsBet (-107)
  • 49ers - PointsBet (-107)


  • Over - PointsBet (-105)
  • Under - BetMGM (-110)

Want more NFL Betting news and analysis? Be sure to check back frequently on Canadian Sports Betting for all the best NFL betting tips and news including weekly picks and NFL Futures Odds.

Follow us on Twitter @cdnbetting for all the latest sports betting news and analysis in the Great White North.

Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.