Monday Night Football Best Bets: Week 11

Get all the Best Bets on this Primetime Game Between the San Francisco 49ers and Arizona Cardinals

Monday Night Football Best Bets: 49ers VS Cardinals

It’s time to finish off another fantastic week of NFL action as we head South of the United States border to Mexico City where two divisional rivals will do battle in an international setting. The San Francisco 49ers will square off against the Arizona Cardinals as both teams continue to hunt down the Seattle Seahawks for the top spot in the NFC West.

With plenty on the line in this high stakes matchup, close out Week 11 with a win using our 49ers VS Cardinals best bets. Here you will find all of the top moneymaking wagers available on this divisional tilt that will get you paid, finishing the week off with a win.

Not only do we supply you with the top NFL picks and predictions on each primetime game, at Canadian Sports Betting, we’ve scoured the market for the top NFL sportsbooks and have compiled an in-depth list of the best online betting sites available in your region. Find the bookmaker that’s right for you, sign up, place a bet on the NFL, and win using our best bets on the 49ers VS Cardinals tonight.

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Monday Night Football Week 11 Picks

In a showdown that is sure to excite and delight fans in Mexico City, this will be an action-packed edition of Monday Night Football. As the 49ers continue to improve and appear to be legitimate Super Bowl contenders, the Cardinals are a team you can never count out thanks to their explosive offensive style.

Last week the 49ers got the job done on primetime as they look to extend their win streak to three against the Cardinals. In week 10 the Niners defeated the Los Angeles Chargers in a come from behind victory that helped solidify this teams ability to respond against adversity. As they are in position to usurp the Seahawks from atop the divisions standings, a win on Monday Night Football will be crucial in doing so.

On the other side of the field sit a team that may not be having the season they expected, but could still have a chance at cracking into the Playoffs with a win against the 49ers.

The Cardinals have certainly had their struggles this season, lacking the overall team chemistry to preserve through the hardships of the season. The Cardinals will need to get on the right track if they’ve got any hopes in taking down a tough 49ers squad.

Moneyline/Point Spread Pick: San Francisco 49ers (ML/-8)

In tonight’s primetime showdown, we are backing the San Francisco 49ers to continue their recent success at the expense of the Arizona Cardinals.

With the 49ers offence being incredibly difficult to bottle up, the Cardinals are going to struggle mightily to contain the run. One of the best downhill running squads in the NFL, the 49ers embrace smash mouth football and look to plunge down the middle of the field for long and methodical drives.

Facing one of the worst run defences in the entire NFL, the Cardinals are in one of the worst possible scenarios for team. With no hope in stopping the run, the Cardinals are going to be forced to rely on their offence to put up big scoring numbers against a 49ers defence that allows the fourth-fewest points per game in the league.

Look for the 49ers to control the matchup from start to finish as they continue to pick up steam and continue their journey back to the NFL Playoffs, crushing the Cardinals on Monday Night Football in the process. Bet the 49ers to win the game handily, covering the eight-point spread

Over/Under Pick: Over 43.5 Points

A modest point total in the NFL, look for these divisional rivals to score in bunches, lighting up the scoreboard and hitting the Over on your bet slip.

Both teams in tonights matchup are capable of providing football fans with high-scoring outputs. With superstars on both sidelines, either side is ready to break off a big play at a moments notice. Players such as DeAndre Hopkins, Christian McCaffrey and others have a nose for the end zone and will more than likely find their way to hit paydirt over the course of this matchup

When you bet the Over tonight, the odds are in your favour. This season in the 16 matchups that have had a point total of 43.5, nine of those games (56.25%) have gone Over. Look for this trend to continue in tonight’s matchup between the 49ers and Cardinals.

Best Monday Night Football Player Prop Bets

Another terrific way to bet on the NFL, player prop bets are fun and exciting alternative to traditional betting markets. These prop bets allow you to wager on the performance of an individual player from a game.

Whether it’s to score a touchdown, or fail to make a certain amount of receptions, player prop bets provide an entirely new way to bet on the NFL. Get in on the best NFL player prop bets for Monday Night Football below.

Elijah Mitchell Anytime Touchdown Scorer

Returning last week after suffering an MCL sprain in Week 1, Elijah Mitchell got plenty of touches in the 49ers backfield. Even after acquiring All-Pro running back Christian McCaffrey from the Carolina Panthers, Mitchell has continued to be a focal point of the 49ers offensive scheme.

Watch for the 49ers to continue feeding Mitchell the rock on multiple different sets, providing him with ample opportunity to find the end zone against the weak Card’s defence. Back Mitchell to become an anytime touchdown scorer and hit paydirt alongside him on Monday Night Football.

James Conner Under 49.5 Rushing Yards

A strong downhill runner, James Conner has become a mainstay among the NFLs top running backs. After missing multiple weeks due to injury, Conner has looked strong since his return. While he’s more than capable of racking up yardage for his team, look for Conner to be held under 49.5 rushing yards against the 49ers.

The Cardinals leading rusher is going to have a tough night at the office against a 49ers defence that excels at stopping the run. Allowing the second-fewest rushing yards against per game, Conner will have trouble breaking through the line and securing first downs, leaving him with a low total yardage in tonight’s primetime matchup.

CSBs Best Same Game Parlay

Looking to get the best bang for your buck betting on the NFL? With same game parlays you can combine multiple selections into one bet, then wager on the combined odds of each additional leg added. But there’s a catch, if even a single bet added to your wager loses, so does the entire parlay.

Place a same game parlay on the 49ers VS Cardinals, encapsulate every area of the game into one profitable bet, and use our pre-built Monday Night Parlay found below.

  • DeAndre Hopkins Anytime Touchdown Scorer
  • Jimmy Garoppolo Over 199.5 Passing Yards
  • George Kittle Under 59.5 Receiving Yards

Total Odds: +415

A great way to get insight on an NFL matchup, reviewing the public betting trends of a matchup allows you to see where you stand among the sports betting community. Whether you want to fade the public or put the fate of your bets in their hands, reviewing public betting trends can be a great tool in crafting your next winning bet.

Find the latest public betting trends on the 49ers VS Cardinals below and use this statistics to help decide where you want to lean on Monday Night Football.


  • San Francisco 49ers - 80%
  • Arizona Cardinals - 20%

Point Spread

  • San Francisco 49ers - 44%
  • Arizona Cardinals - 56%


  • Over 43.5 - 70%
  • Under 43.5 - 30%

San Francisco 49ers VS Arizona Cardinals Injury Report

Before placing a bet on any sport, it’s imperative to check out the latest injury reports available for a matchup. If even a single player is ruled out of a game, this could completely change your outlook on a game, as well as shift the odds & lines of a matchup.

Get the latest NFL injury report for the 49ers and Cardinals below, make note of who will be missing in action, and use this information to make your next bet a winner.

Best Lines & Odds on the 49ers VS Cardinals

If you’re going to bet on the NFL, make sure you are maximizing your winning potential. By line shopping for the best odds available on a betting market, you will set yourself up to generate the best possible profit margin on your wagers.

Instead of spending the day crunching numbers and comparing oddsmakers, we’ve compiled the best odds from the top online sportsbooks so you can get the best odds in an instant, and win big with CSB.


  • San Francisco 49ers - BetMGM (-350)
  • Arizona Cardinals - Bet365 (+300)

Point Spread

  • San Francisco 49ers - PointsBet (-107)
  • Arizona Cardinals - PointsBet (-107)


  • Over - PointsBet (-107)
  • Under - PointsBet (-107)

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Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.