Monday Night Football Best Bets: Week 4

Get all the Best Bets on the Monday Night Showdown between the Los Angeles Rams and San Fransisco 49ers

MNF Best Bets: Rams VS 49ers

Don’t miss out on this primetime matchup that’s sure to be filled with big hits, crazy catches, and spectacular performances. The only way to take the excitement of this game to the next level is by putting yourself in the game and placing your bets on the Rams VS 49ers.

Want to place a bet on Monday Night Football but aren’t sure where to start? Check out the top NFL sportsbooks available in your region, find the oddsmaker thats right for you, and place your first bet on Monday Night Football or take a chance at predicting who’s going to claim the Lombardi Trophy and place a futures wager on this years Super Bowl odds.

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Standard Bets

Whether you’re new to NFL betting or are experienced with NFL betting, you can never go wrong wagering on the traditional bet markets like moneylines, point spreads, and point totals. All of these betting options are easy to wager on and can help you develop more in-depth betting strategies.

Below you can find our picks for the Monday Night Football Rams VS 49ers!

Moneyline/Point Spread Pick: Los Angeles Rams (ML/+1.5)

In this rematch of the 2022 NFC Championship game, the Los Angeles Rams visit the San Fransisco 49ers in Levi’s Stadium looking to repeat their winning performance from last postseason.

Even in this young season, there have been plenty of ups and downs for the 49ers thus far. Battling through constant injuries and changing lineups, the 49ers have struggled to put together consistent success. Going up against a well-oiled machine in the Rams, the 49ers might struggle to get the ball downfield.

While both teams sports top defences in the NFL, the Rams are the more dangerous offensive team. The Rams have several legitimate scoring options while the Jimmy Garoppolo led 49ers have struggled to get the ball into the hands of their top playmakers.

It may be a gritty, grind it out matchup, but the Rams have the higher upside, back the Rams moneyline or to cover a slim (+1.5) point spread.

Over/Under Pick: Under 42.5 Total Points

It’s no secret that the key to both of these teams success is reliant on their tremendous defences. With stars all over the field, it is going to be incredibly difficult for either team to hit paydirt in this one.

On top of this the 49ers are a run-heavy offence, they love to control the rock and drain the clock in hopes of controlling the pace of the ball game. In a matchup between two of the best football minds in the NFL, Sean McVay and Kyle Shanahan will jockey to outwit the other as they try and will their team to victory.

Both teams are going to bring the heat on defence, don’t expect a high-scoring game, bet the Under on Monday Night Football.

Best Player Prop Bets

Other than wagering on the game’s outcome, player prop bets are a fun way to wager on any game. Here you can bet on player specific events occurring within a matchup.

Below you can find some of our best player prop bets that are sure to add some juice to your Monday Night Football betslips.

Matthew Stafford Over 1.5 Passing Touchdowns

Even when facing one of the best secondaries in the NFL, don’t count out Matthew Stafford from throwing a few darts into the end zone in this primetime matchup. Stafford has proven he’s more than able to move the ball to his receivers even against the best defences in the NFL and this won’t change on Monday Night.

The 49ers haven’t faced a gunslinger like Stafford yet this season so this will be a true test of their abilities. Additionally, the run game for the Rams has been sketchy to start the season so look for the Rams to keep the ball moving through the air, and as a result score Stafford over 1.5 passing touchdowns.

Nick Bosa Over 0.25 Sacks

One of the top edge rushers in the NFL, Nick Bosa is a one-man wrecking crew. With his ability to bulldoze through linemen or evade blocks with finesse and technique, there’s almost no way to stop Bosa.

The Rams have allowed the seventh-most sacks in the NFL this season and with uncertainty surrounding their o-line, look for Bosa to take advantadge and secure at least a half-sack in this marquee matchup. Bet Nick Bosa’s Over on total sacks.

CSBs Best Same Game Parlay

Same game parlays (SGP) are one of the hottest ways to bet on any sporting event, allowing for players to stack multiple wagers on a single event into one betslip.

At CSB we want to give you a same game parlay that could hand you your first SGP victory. We kept it simple but this safe SGP has some great value attached for all bettors to take advantage of.

  • Los Angeles Rams Moneyline
  • Matthew Stafford Over 255+ Passing Yards
  • George Kittle Over 39.5 Receiving Yards

Total Odds: +425

Knowing where the public is leaning can be a fantastic tool when determining how you want to wager on a matchup. Whether you decide to fade or ride with the public betting trends, having an idea of how the masses are betting is a great way to analyze how you see a matchup.

Find the public betting trends for the Rams VS 49ers below.


  • Los Angeles Rams - 83%
  • San Fransisco 49ers - 17%

Point Spread

  • Los Angeles Rams - 74%
  • San Fransisco 49ers - 26%


  • Over 42.5 - 63%
  • Under 42.5 - 37%

Injury Reports

Being informed on who is going to be suiting up for any matchup is essential before placing any wager. If a star player is a game-time decision, it may be best to steer clear of wagering on their team. Find all of the reported player injuries heading into the Monday Night Football matchups below.

Los Angeles RamsSan Fransisco 49ers
CB Derion Kendrick (Questionable, Concussion)DL Arik Armstead (Questionable, Foot)
S Jordan Fuller (Questionable, Hamstring)TE Ross Dwelley (Questionable, Ribs)
CB David Long Jr. (Questionable, Groin)S Tarvarius Moore (Questionable, Undisclosed)
CB Cobie Durant (Questionable, Undisclosed)DL Javon Kinlaw (Questionable, Undisclosed)
OL Brian Allen (Questionable, Undisclosed)WR Danny Gray (Questionable, Hip)
S Quentin Lake (Out, Knee)OL Daniel Brunskill (Questionable, Undisclosed)
LB Travin Howard (Out, Groin)OL Trent Williams (Out, Ankle)
WR Van Jefferson (IR, Knee)LB Azeez Al-Shaair (Out, Knee)
OL Tremayne Anchrum Jr. (IR, Lower Leg)TE Tyler Kroft (Out, Undisclosed)
CB Troy Hill (IR, Groin)RB Tyrion Davis-Price (Out, Undisclosed)
RB Kyren Williams (IR, Ankle)DL Kalia Davis (Out, Undisclosed)
LB Daniel Hardy (IR, Ankle)CB Jason Verrett (Out, Undisclosed)
OL Logan Bruss (IR, Knee)QB Trey Lance (IR, Ankle)
WR J.J. Koski (IR, Shoulder)DL Jordan Willis (IR, Undisclosed)
RB Elijah Mitchell (IR, Knee)
CB Jimmie Ward (IR, Hamstring)
LB Curtis Robinson (IR, Ankle)
TE Jordan Matthews (IR, Knee)
DL Maurice Hurst (IR, Biceps)

Best Lines & Odds

The process of comparing odds between sportsbooks and breaking down where you’ll get the best value for your bet can be a painstaking ordeal. That’s why at Canadian Sports Betting, we’ve scoured through the best lines from top sportsbooks so you know where and what to bet on these primetime matchups.


Point Spread


Want more NFL Betting news and analysis? Be sure to check back frequently on Canadian Sports Betting for all the best NFL betting tips and news including weekly picks and NFL Futures Odds.

Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.