NFL Thanksgiving Day Games Best Bets: Bills VS Lions

Get the Latest Odds and Winning Wagers for the Buffalo Bills VS Detroit Lions

Buffalo Bills VS Detroit Lions Best Bets

It’s Turkey day in the USA, which means all-day NFL action for all of us North of the Border. With three games running consecutively throughout the day, there will be no shortage of action to bet of. The first of the three games set to kickoff off Thursday is between the Buffalo Bills (7-3) and Detroit Lions (4-6).

With Canadian Sports Betting, you can get all of the best bets, winning wagers, and top picks, all in one place so you can feast on NFL betting wins all-day long. You can catch all the best betting advice and analysis for every primetime NFL game here so you can start bringing in the big bucks on your NFL wagers.

Not only do we supply you with the best bets and advice for the NFL, we also show you the top online sportsbooks available for NFL betting. All of our featured NFL betting sites have been carefully reviewed and vetted for their legitimacy, safety, and sportsbook features. Find the NFL sportsbook for you, sign up, deposit, and place your first winning bet using our Bills VS Lions picks.

Signup & Download DraftKings Today

Bills VS Lions Picks

In a duel between two of the NFLs most dangerous offences, the Buffalo Bills will play their second-straight week out of Ford Field, but this time as the visiting team against the hometown Detroit Lions. In a matchup that is sure to feature plenty of huge plays and spectacular highlights, take the action to the next level by placing a bet on the Bills VS Lions.

Coming off of a win over the Cleveland Browns last week, the Buffalo Bills have continued rolling as they build upon their Super Bowl candidacy. The Bills have looked impressive so far this season and have not faltered in the face of adversity.

Ready to take another step towards the NFL Playoffs, they will have a tough task on hand as they face the Detroit Lions.

Quietly riding a three-game winning streak, the Lions are looking to capture the franchises biggest win in years with a victory over the Bills. The Lions have had several down to the wire battles this season, but unfortunately for them and their fans, have failed to come out on top in the majority of those games.

With their backs against the walls it’s officially do-or-die for the Lions season, and to stay alive they will need to find a way to stop the high-powered Bills offence led by Josh Allen.

Moneyline/Point Spread Pick: Buffalo Bills (ML/-9.5)

While the Lions are a force to be reckoned with offensively, they will still have their hands-full taking on the Bills hard-hitting defence. One of the top defences in the NFL, the Bills have made mince meat of opposing offences, exceling at getting to the quarterback as well as locking down the passing game.

Additionally, the Bills offence packs a punch themselves, currently only trailing the Kansas City Chiefs in points scored per game. Set to square of with the leagues worst defence, things could get disastrous for the Lions. Currently allowing the most-points against per game in the entire NFL, look for the Bills to decimate the Lions on the scoreboard.

This matchup is a perfect example of a decent team facing a great team, once they take the field you’ll have no problem differentiating which is which. Back the Buffalo Bills to win the game on both sides of the football, kicking off your NFL Thanksgiving Day slate with a win.

Over/Under Pick: Under 54 Points

Only once this season have we seen a point total of this magnitude, that coming in the Week 3 matchup between the Bills and Miami Dolphins, a game in which only 40 total points were scored.

It’s no secret that both of these teams like to score the football. In a showdown between two top-10 scoring offences, generally speaking you’d expect the Over to be a lock, but not so fast.

With defence comprising 50% of the game, they need to be looped into this equation. As the Bills defence gears up for another dominant display, we may see an uncharacteristic outing for the Lions offence. If they are unable to put up the yardage they’ve grown accustomed to over the past few weeks, the Lions could easily be shutdown early on into this game.

The Bills are well-experienced at playing and maintaining leads, which will help play into the final score of this matchup. Having no shortage of scoring opportunities in this matchup, the Bills may opt to control the clock and prevent the Lions from touching the football as much as possible.

Back the Bills to keep things low-scoring as they control the rock and drain the clock, resulting in Under 54 total points.

NFL Thanksgiving Day Player Prop Bets

Not only are there great bets to be placed on the outcome of the Bills VS Lions, but you can also bet beyond that and place several terrific player prop bets. Player prop bets are wagers on a individual players performance within a specific game.

Below you will find the top moneymaking player prop bets available on this Thanksgiving Day game. Don’t be a turkey, place a player prop bet on the Bills VS Lions matchup today.

Josh Allen Over 42.5 Rushing Yards

One of the premier dual-threat quarterbacks in the NFL, Josh Allen is looking to move his legs to get you paid with this terrific player prop bet. Coming off a rare low-rushing total against the Browns, look for Allen to get back on track, sprinting for well over 42.5 yards against the Lions.

This bet is a fantastic wager to make as the Detroit Lions have given up exactly 42.5 rushing yards per game to opposing quarterbacks this season. With Allen posing a much larger threat to the Lions defence in comparison to some of the other passers they’ve faced this season, look for Allen to shatter this line and score you an easy payday.

Jamaal Williams Anytime Touchdown Scorer

If the season ended today, Jamaal Williams would be the 2022 NFL touchdown king. Currently sitting with 12 total touchdowns this season (all rushing), Williams has shown he can be one of the best tailbacks in the NFL at punching into the end zone when his number is called.

A dynamic runner, Williams has the power to lower his shoulder into oncoming defenders, as well as possesses elite level speed when he reaches his top gear. Even against a solid defence like the Bills, look for Williams to plunge his way into the end zone, amassing his 13th touchdown in 10 games played.

Bills VS Lions Same Game Parlay

One of the best ways to get the most out of your wagers, same game parlay betting allows you to turn chump change into big baller dollars. By adding multiple bet selections from a single game into one bet slip, you can increase the odds of your bet with each additional leg.

This can result in massive potential payouts but there’s a catch. In order to be paid out a winner, each wager must be successful, if even a single wager falls shorts, the entire bet loses.

To get started with same game parlays, take advantage of our pre-built Bills VS Lions same game parlays o you can get paid on NFL Thanksgiving Day.

  • Dawson Knox Anytime Touchdown Scorer
  • Gabe Davis Over 54.5 Receiving Yards
  • Jared Goff Over 224.5 Passing Yards

Total Odds: (+475)

Ever wonder how the average bettors bet slip looks before you wager on an NFL matchup? Well wonder no longer thanks to NFL public betting trends. By reviewing the latest public betting trends you can see where the majority of bettors are leaning on any given matchup.

By seeing where the public money is placed, this can influence you to ride with the masses or to fade them and carve out your own path to NFL betting glory. Check out the latest NFL public betting trends for the Bills VS Lions and use this data to help you formulate your next NFL wager.

Buffalo Bills - 76%

Detroit Lions - 24%

Buffalo Bills - 46%

Detroit Lions - 54%

Over - 56%

Under - 44%

Bills VS Lions Injury Report

One of the most important things to check before betting on any game is the latest injury reports. By staying informed on who is in or out of a matchup, or even who might not be at 100%, injury reports provide valuable information for your future bets.

Review the latest and up-to-date NFL injury reports for both the Bills and Lions below, see who will be ready for kickoff on Thanksgiving, and place your bets accordingly.

Best NFL Thursday Night Football Lines & Odds

If you’re going to bet on the Bills VS Lions, you may as well make sure you are getting the biggest possible payout. Each online sportsbook offers slightly varied lines & odds on each NFL matchup, so we’ve compiled the best odds as well as the sportsbook providing them so you can maximize your winning potential.

Score your biggest NFL betting win yet by using the NFL sportsbook with the best odds & lines available on the Bills VS Lions.


Buffalo Bills - BetRivers (-420)

Detroit Lions - Bet365 (+375)

Point Spread

Buffalo Bills - DraftKings (-110)

Detroit Lions - PointsBet (-105)


Over - PointsBet (-107)

Under - PointsBet (-107)

Want to stay up to date with all of the latest NFL betting news? Canadian Sports Betting has all of the best bets, picks, & predictions on all the top sports. Our sports betting news is updated daily so you can place winning wagers weekly or on NFL Futures like odds on the upcoming Super Bowl.

Follow us on Twitter @cdnbetting for more betting updates, news, and exclusive picks!

Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.