Thursday Night Football Best Bets Week 15: 49ers VS Seahawks

Get the Latest Odds and Best Bets on the 49ers VS Seahawks

Thursday Night Football Week 15 Picks

It’s time to kick off Week 15 of the NFL season as we have a huge matchup on Thursday Night Football with major playoff implications. We head to the NFC West for this evening’s primetime clash as the San Francisco 49ers (9-4) have an opportunity to clinch the division title with a win over the Seattle Seahawks (7-6).

With stakes at an all-time high, it’s only right you get some skin in on the game and place a bet on tonight’s NFL action. At Canadian Sports Betting, we have all the best bets and expert betting analysis at your disposal so you can pile up your winnings higher than Mount Logan.

Not only do we supply you with the best bets and winning wagers available on the 49ers VS Seahawks, but at Canadian Sports Betting we also provide you with the top online sportsbooks available in your region. Find the NFL betting site that works for you using our in-depth sportsbook reviews, sign up, deposit, and lace ‘em up as you throw down your first winning bet on the NFL.

San Francisco 49ers VS Seattle Seahawks Best Bets

In a duel between the top teams in the NFC West, the 49ers and Seahawks will duke it with a guaranteed home-field advantage in the playoffs on the line. In a showdown between the league’s top defence and one of the most explosive offensive units in the NFL, there is sure to be no shortage of highlight plays in tonight’s contest.

Riding an impressive six-game winning streak, the 49ers have moulded themselves into legitimate Super Bowl contenders. Sporting the top defensive unit in the NFL, the 49ers take no prisoners on the gridiron, holding their opponents to under 20 points during their hot streak.

Looking to capture their biggest win of the season, the 49ers are going to leave it all on the field in order to set themselves up for success in the NFL Playoffs.

On the other side of the fray, the Seattle Seahawks have shocked many with their success this season. With many expecting to see the decline of one of the top franchises in the past decade, Pete Carroll’s squad has continued to find ways to win week in and week out. Not wanting to surrender the division crown, the Seahawks will need to put on a masterclass to defeat the red-hot 49ers.

Moneyline/Point Spread Pick: San Francisco 49ers (ML/-3.5)

Right now there appears to be no slowing down the 49ers, look for this trend to continue as they claim their seventh consecutive win at the expense of the Seahawks.

Led by former “Mr. Irrelevant” Brock Purdy, the 49ers have taken a stranglehold over the NFC West and there’s seemingly nothing any team can do to stop it. With their defence firing on all cylinders and their offence not skipping a beat with their new quarterback, the 49ers could be the team to beat in the NFL.

The 49ers will have no trouble moving the ball downfield against the Seahawks, utilizing their superb running attack to plunge their way through the trenches, picking up big-time yardage as a result. With superstar running back Christian McCaffrey playing out of his mind, the Seahawks will be grasping at straws in an attempt to neutralize the weapons of the 49ers offence.

On the flip side of this game, while the Seahawks offence was electric to start the year, their total production has certainly diminished over the past few weeks. Still putting up strong scoring numbers, the big play potential of the Seahawks is still present, but they are having a tougher time executing their short plays as teams have begun to grow wise of the resurgent Geno Smith.

Look for the 49ers defence to keep the Seahawks in a box, limiting their production and controlling the pace of the game from start to finish. Bet the 49ers Moneyline on Thursday Night Football as they continue on their path toward the NFL Playoffs as they search for the franchise’s sixth Lombardi Trophy.

Over/Under Pick: Under 43.5

Both teams in tonight’s primetime showdown are willing and able to light up the scoreboard, but with playoff seeding on the line, look for both sides to take a more calculated approach in tonight’s ball game.

The 49ers have limited their opponents offensively this season, both on the ground and through the air, giving zero wiggle room to find the end zone. A brick wall on the field, the 49ers defence currently allows a league-best 15.2 points per game against, an impressive feat to say the least.

Offensively, the 49ers are no strangers to playing smashmouth football, grinding out the clock and moving down the field methodically. Milking the clock and controlling the rock has been a winning philosophy in Kyle Shanahan’s offence for several years now and could be what secures them the victory over the Seahawks on Thursday Night Football.

Look for the 49ers to command the lead and control the clock, forcing the Seahawks to play desperately against their powerhouse defence. Bet the Under on the 49ers vs Seahawks and watch your bankroll skyrocket while the score stays low.

Thursday Night Football Player Prop Bets

Not only can you place several moneymaking wagers on the outcome of the 49ers VS Seahawks, but in a star-studded matchup, player prop bets are a great bet to place to spice up your NFL bet slip.

Player prop bets allow NFL bettors to wager on the individual performance of a specific player, rather than the outcome of the game. This could be anything from an Over/Under wager on passing yards, interceptions thrown, or an any-time touchdown scorer.

Place a player prop bet on Thursday Night Football using our best player prop bets found below.

Christian McCaffrey Anytime Touchdown Scorer (-150)

One of the most versatile players to ever grace the football field, Christian McCaffrey has been absolutely balling out since joining the 49ers after being shipped off from the Carolina Panthers. Coming off of a two-touchdown performance in his last outing against the Tampa Bay Buccaneers, look for CMC to keep on picking up steam, finding his way into the end zone over the course of the 60 minutes of play.

Able to hurt defences both on the ground as well as as a receiver, McCaffrey is a nearly unstoppable player. The definition of a dual-threat athlete, look for McCaffrey to continue building momentum against the Seahawks, helping you hit paydirt as an anytime touchdown scorer in the process.

Geno Smith Under 1.5 Passing Touchdowns (-165)

A favourite for this season’s Comeback Player of the Year Award, don’t expect to see quarterback Geno Smith find the usual success he has grown accustomed to this season.

Playing exceptionally well this year, Smith has been held Under 1.5 touchdown passes twice this season, both instances coming from divisional matchups. With the 49ers defence locked and loaded, ready to shoot down any momentum the Seahawks attempt to build, look for Smith to have a rare off night, throwing for Under 1.5 touchdowns in a tough matchup against the 49ers.

49ers VS Seahawks Same Game Parlay

A thrilling way to bet on the NFL, same game parlays allow NFL bettors to combine game lines with player prop bets, resulting in incredibly juicy odds that could net you a hefty payday.

With each bet selection added the odds on your parlay bet will increase, however, if even a single bet loses on your parlay, the entire wager loses. Craft your own unique NFL bet slip today on the 49ers VS Seahawks or take advantage of our pre-built same game parlay to get you paid on Thursday Night Football.

  • Christian McCaffrey Over 64.5 Rushing Yards
  • Brandon Aiyuk over 49.5 Receiving Yards
  • Seattle Seahawks Under 1.5 Total Touchdowns

Total Odds: (+500)

A great way to get a valuable second opinion on your NFL bets, NFL public betting trends provide you with the best possible focus group a sports bettor could ask for. Instead of asking your friends for more whack betting advice, see where the majority of bettors are leaning on a specific matchup.

NFL public betting trends show you where the majority of bettors are wagering their money on each major betting market. See where the public is leaning and use this information to help you craft your 49ers VS Seahawks bets.

San Francisco 49ers - 79%

Seattle Seahawks - 21%

San Francisco 49ers (-3.5) - 74%

Seattle Seahawks (+3.5) - 26%

Over 43.5 - 65%

Under 43.5 - 35%

49ers VS Seahawks Injury Report

A must before placing a bet on the NFL, be sure to review the latest NFL injury report. With injuries piling up across the NFL late into the season, players are in and out of games on a weekly basis. The absence of one player is enough to sway the lines as well as alter the outcome of the game, and therefore your bets.

Check out the latest NFL injury report for both teams, factor this into your 49ers VS Seahawks bets, and bet with the best information available.

Best NFL Thursday Night Football Lines & Odds

If you’re going to place a bet on the 49ers VS Seahawks, make sure you’re doing it at a sportsbook with the best odds & lines available. Maximizing your winning potential is a must for NFL bettors as you’ve never thought to yourself “I won too much money.”

Break the bank and bring home a big bag. Find the best odds & lines on Thursday Night Football, follow our direct links to the applicable sportsbook, and score your biggest win of the NFL season.


San Francisco 49ers - Bet365 (-170)

Seattle Seahawks - BetRivers (+155)

Point Spread

San Francisco 49ers (-3.5) - DraftKings (+100)

Seattle Seahawks (+3.5) - Bet365 (+100)


Over 43.5 - PointsBet (-107)

Under 43.5 - PointsBet (-107)

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Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.