Thursday Night Football Best Bets: Week 5

Can the Denver Broncos Bounce Back Against the Indianapolis Colts on TNF?

TNF Best Bets: Colts VS Broncos

Kicking off Week 5 with a solid matchup between two teams desperate to get their season back on track, as the Denver Broncos (2-2) play host to the Indianapolis Colts (1-2-1). Both teams are coming off of disappointing losses in Week 4 and will be desperate to get back into the win column this week.

It’s hard to elevate the excitement of Thursday Night Football, but by betting on the game the thrill of watching NFL action reaches new heights. Getting some skin in on the game is a great way to turn any game into a must-see matchup, as you could walkaway a winner after placing your stake in the contest

Looking to place a bet on Thursday Night Football but don’t know where to start? Check out the top NFL sportsbooks available in your region, find the oddsmaker that’s right for you, and place your first bet on the Colts VS Broncos or maybe even a futures wager on this year’s Super Bowl odds.

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Standard Bets

Regardless if you’re new to betting on the NFL or consider yourself an experienced football handicapper, you can never go wrong wagering on the traditional bet markets like moneylines, point spreads, and point totals.

Below you can find our picks for the Colts VS Broncos matchup!

Moneyline/Point Spread Picks: Denver Broncos (ML/-3.5)

Both the Colts and Broncos entered this season as playoff hopefuls but certainly haven’t lived up to expectations. With their own struggles on both sides of the ball, neither squad has been able to find their identity yet this season.

In this primetime matchup we got our money on the home team Denver Broncos. With Russell Wilson finally starting to look comfortable in the orange and navy, the Colts defence will struggle to contain the Pro Bowl quarterback. This is only amplified as the Colts defence will be without superstar linebacker Shaquille Leonard who is out due to a concussion suffered in Week 4 against the Tennessee Titans.

With the Colts defence banged up, they may have a tough time sending pressure towards Wilson. This will allow Russ to cook in the pocket as he finds his receivers downfield in favourable matchups against a weak Colts secondary.

Additionally to their injury woes, Colts star running back Johnathon Taylor has been ruled out for this marquee matchup due to an ankle injury. Taylor is the heart and soul of the Colts offence and without him their production will only worsen as the game goes on.

On the Broncos sideline they are dealing with several injuries to key players of their own, most notably losing running back Javonte Williams for the season after he tore his ACL against the Las Vegas Raiders. With second-string running back Melvin Gordon III stepping up to fill the void, it remains uncertain if he can produce at the same rate as Williams was so far this season.

Take the Denver Broncos moneyline or to cover the 3.5-point spread over the Indianapolis Colts on Thursday Night Football.

Over/Under Pick: Under 42.5 Total Points

It’s no secret that neither team has really found any sort of groove offensively. The Broncos have struggled to produce consistently on drives due to new personnel and at times inept coaching, and the Colts have continually failed to get their best players activated and involved over the course of a game.

Both teams possess strong run defence which negates the primary offensive game plan of both squads. If neither team can manage to find a hole in the oppositions defence early on, it could be a matchup relying on conservative plays for safe yardage each series.

With neither teams offence being reliable, the Under is the best bet when wagering on the point total for Thursday Night Football.

Best Player Prop Bets

Other then wagering on the outcome of the game, player bets are a fun way to wager on any NFL matchup. With these bets you can wager on player-specific events occurring within a matchup which can include a player scoring a touchdown, over/under on various stats and more.

Below you can find some of our best player prop bets that are sure to add some spice to your Colts VS Broncos betslip.

Courtland Sutton Over 64.5 Receiving Yards

Posting some of the best numbers of his career so far this season, wideout Courtland Sutton has been one of the lone bright spots on a porous Broncos offence. So far this season Sutton has only been held under 65 yards receiving once, all other appearances he easily eclipsed the mark.

Able to create space for himself with ease in the open field, look for Sutton to rack up big yardage in this game as the Colts struggle to find a cornerback that can matchup with the big bodied wide receiver.

Over 7.5 Total Punts

We hope it doesn’t come to this, but if it does you can at least make some scratch off of it. The over on total punts is a great wager for all NFL bettors.

The Broncos are currently averaging the second most punts per game in the NFL with 5.3 punts a contest, while the Colts remain one of the teams that punts the fewest at three punts per game. This matchup will be reliant on strong defence, look for both teams to play conservatively and punt the ball plenty in this Thursday Night tilt.

CSBs Best Same Game Parlay

Same game parlays (SGP) are one of the best ways to bet on any sporting event, allowing players to stack multiple wagers on a single event into one betslip.

At CSB we want to give you a same game parlay that could hand you your first SGP victory. We kept it simple but this safe SGP has some great value attached for all bettors to take advantage of.

  • Melvin Gordon Anytime Touchdown Scorer
  • Russell Wilson Over 194.5 Passing Yards
  • Michael Pittman Jr. Over 54.5 Receiving Yards

Total Odds: +330

Knowing where the public is putting their money can be a fantastic tool when determining how you want to bet on a matchup. Seeing where the majority of NFL bettors are placing their wagers can either discourage or entice you to follow in their footsteps. Find the public betting trends for the Colts VS Broncos below.


  • Indianapolis Colts - 40%
  • Denver Broncos - 60%

Point Spread

  • Indianapolis Colts - 44%
  • Denver Broncos - 56%


  • Over 42.5 - 29%
  • Under 42.5 - 71%

Injury Reports

Being informed on who is going to be suiting up for any matchup is essential before placing any wager. If a star player is a game-time decision, it may be best to steer clear of wagering on their team. Find all of the reported player injuries heading into the Dolphins VS Broncos matchup below.

Indianapolis ColtsDenver Broncos
DL Kameron Cline (Questionable, Concussion)RB Melvin Gordon (Questionable, Neck)
S Julian Blackmon (Questionable, Undisclosed)WR Tyree Cleveland (Questionable, Hamstring)
RB Johnathon Taylor (Out, Ankle)QB Russell Wilson (Questionable, Shoulder)
LB Shaquille Leonard (Out, Concussion/Nose)OL Billy Turner (Questionable, Undisclosed)
DL Tyquan Lewis (Out, Concussion)CB Darius Phillips (Questionable, Undisclosed)
S Trevor Denbow (IR, Undisclosed)OL Quinn Meinerz (Questionable, Undisclosed)
P Rigoberto Sanchez (IR, Achilles)LB Jonathon Cooper (Questionable, Undisclosed)
S Armani Watts (IR, Ankle)S Cade Sterns (Questionable, Undisclosed)
TE Andrew Ogletree (IR, Knee)LB Aaron Patrick (Questionable, Concussion)
OL Carter O’Donnell (IR, Undisclosed)S P.J. Locke (Questionable, Concussion)
OL Tom Compton (Out, Back)
LB Randy Gregory (IR, Knee)
TE Greg Dulcich (IR, Hamstring)
RB Javonte Williams (IR, Knee)
S Justin Simmons (IR, Quadriceps)
CB Michael Ojemudia (IR, Elbow)
OL Casey Tucker (IR, Toe)
WR Tim Patrick (IR, Knee)
LB Christopher Allen (IR, Foot)
RB Damarea Crockett (IR, Knee)

Best Lines & Odds

The process of comparing odds and breaking down where you’ll get the best value for your bet can be a painstaking ordeal, thats why at Canadian Sports Betting, we’ve scoured through the best lines from top sportsbooks so you know what to bet and where on this primetime matchup.


Point Spread

  • Indianapolis Colts - Bet365 (+100)
  • Denver Broncos - PointsBet (+100)


  • Over - PointsBet (-107)
  • Under - BetRivers (-107)

Want more NFL Betting news and analysis? Be sure to check back frequently on Canadian Sports Betting for all the best NFL betting tips and news including weekly picks and NFL Futures Odds.

Matt Eichhorn

Matt Eichhorn

Having worked in the Sports Gambling industry since 2020, Eichhorn has expertise in all things sports betting. With experience covering various major North American sports leagues he has a wide array of knowledge to draw from when crafting his work.